June 2019
“Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect”
L. Côrte-Real, B. Karas, A. R. Brás, A. Pilon, F. Avecilla, F. Marques, A. Preto, B. T. Buckley, K. R. Cooper, C. Doherty, M. H. Garcia*, A. Valente*
Inorganic Chemistry 2019, 58, 9135−9149
Doi: https://doi.org/10.1021/acs.inorgchem.9b00735
PhD Thesis: Leonor Côrte-Real, PhD in Chemistry, Faculdade de Ciências da Universidade de Lisboa, June 2019. Thesis titled: “Polymer-metal based compounds to target (non)hormone-responsive cancers: synthesis and mechanistic evaluation”
Leonor was awarded was awarded by the Direcção da Divisão de Química Terapêutica from SPQ as the Portuguese Representative at the 6th Young Medicinal Chemist Symposium where she will present her work.
Leonor was awarded was awarded by the Direcção da Divisão de Química Terapêutica from SPQ as the Portuguese Representative at the 6th Young Medicinal Chemist Symposium where she will present her work.
February 2019
“Polymer “ruthenium-cyclopentadienyl” conjugates - new emerging anti-cancer drugs”
Tiago Moreira, Rita Francisco, Elisabeta Comsa, Sophie Duban-Deweer, Valérie Labas, Ana-Paula Teixeira-Gomes, Lucie Combes-Soia, Fernanda Marques, António Matos, Audrey Favrelle, Cyril Rousseau, Philippe Zinck, Pierre Falson, M. Helena Garcia, Ana Preto, Andreia Valente*
Eur. J. Med. Chem. 2019, 168, 373-384.
Doi: https://doi.org/10.1016/j.ejmech.2019.02.06
Tiago Moreira, Rita Francisco, Elisabeta Comsa, Sophie Duban-Deweer, Valérie Labas, Ana-Paula Teixeira-Gomes, Lucie Combes-Soia, Fernanda Marques, António Matos, Audrey Favrelle, Cyril Rousseau, Philippe Zinck, Pierre Falson, M. Helena Garcia, Ana Preto, Andreia Valente*
Eur. J. Med. Chem. 2019, 168, 373-384.
Doi: https://doi.org/10.1016/j.ejmech.2019.02.06
“Novel screening of transition metal-based anticancer compounds using zebrafish embryo larval assay and ICPMS analysis”.
Brittany Karas, Leonor Côrte-Real, Andreia Valente, Keith R. Cooper, Brian T. Buckley*
J. Appl. Toxicology. 2019, 39, 1173-1180
doi: https://doi.org/10.1002/jat.3802
Brittany Karas, Leonor Côrte-Real, Andreia Valente, Keith R. Cooper, Brian T. Buckley*
J. Appl. Toxicology. 2019, 39, 1173-1180
doi: https://doi.org/10.1002/jat.3802
First Lead4Target team meeting
December 2018
First paper of the project showing the unique dual mode of action of a ruthenium-cyclopentadienyl compound:
“Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand”
Leonor Côrte-Real, Brittany Karas, Patrícia Gírio, Alexis Moreno, Fernando Avecilla, Fernanda Marques, Brian T. Buckley, Keith R. Cooper, Cathleen Doherty, Pierre Falson, M. Helena Garcia*, Andreia Valente*
European Journal of Medicinal Chemistry, 2019, 163, 853-863.
DOI: 10.1016/j.ejmech.2018.12.022
“Unprecedented inhibition of P-gp activity by a novel ruthenium-cyclopentadienyl compound bearing a bipyridine-biotin ligand”
Leonor Côrte-Real, Brittany Karas, Patrícia Gírio, Alexis Moreno, Fernando Avecilla, Fernanda Marques, Brian T. Buckley, Keith R. Cooper, Cathleen Doherty, Pierre Falson, M. Helena Garcia*, Andreia Valente*
European Journal of Medicinal Chemistry, 2019, 163, 853-863.
DOI: 10.1016/j.ejmech.2018.12.022
October 2018
PhD Thesis: Francisco Tortosa, PhD in Medicine, Universitat Autònoma de Barcelona, October 2018. Thesis titled: “Adenomas de la glândula hipofisária: Correlaciones clínico-patológicas e inmunohistoquímicas en un centro de referencia de Portugal”
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